Purpose: This study aimed to analyze the knowledge, attitudes, and compliance with antiretroviral (ARV) antidotes among HIV patients at the Central Bangka Regional General Hospital.

Research Methodology: This study used a qualitative method with a phenomenological approach. The technique for selecting respondents was a non-probability sampling technique, purposive sampling. Nine informants participated in 9 people. Data were collected using an in-depth interview guide.

Results: Findings from the research show that several informants had insufficient knowledge about compliance in taking ARV antidotes. Even though the informants' attitude towards compliance with antiretroviral (ARV) antiretrovirals was relatively good, several key informants stated that they had stopped taking antiretroviral (ARV) antidotes for several months because they felt healthy. However, several months later, they experienced adverse effects that resulted in declining health.

Conclusions: The study concludes that Inadequate knowledge and misconceptions about ARV therapy remain significant obstacles to sustained adherence. Strengthening education, family involvement, and consistent supervision are essential for enhancing compliance and improving health outcomes for people living with HIV.

Limitations: The study was limited to a small number of participants from a single hospital, which restricts broader generalization.

Contribution: This research provides practical insights for healthcare providers and policymakers to design targeted interventions, improve supervision, and foster cross-program collaboration to ensure consistent ARV adherence among patients with HIV, ultimately supporting public health goals in HIV management.