Purpose: This study aimed to determine the significant factors that cause vaccine hesitancy among parents in Bulacan Research methodology: A non-experimental quantitative descriptive research study was used as a research design by using a formulated questionnaire based on the developed tool created by the World Health Organization-Strategic Advisory Group on Experts (SAGE) on Immunization and distributed among the 400 respondents in Bulacan. The respondents were purposively chosen. Results: The result showed that the majority of the parents are hesitant to vaccinate their child, considering that the most common factor causing their decision to have vaccine hesitancy is the scientific evidence of the risk and benefits of vaccination. In addition, there is a weak negative correlation (-0.103) between the economic status of the parents and their vaccine hesitancy regarding the cost of the vaccine. Furthermore, the correlation analysis between the educational attainment of the parents and their vaccine hesitancy is interpreted as a negligible correlation (0.098). Limitations: By COVID-19, the survey questionnaire was conducted through the online platform called Google Form which the study was only limited to parents who have access to the internet. Contribution:  The findings of the study are beneficial to the province of Bulacan for them to further assess and evaluate the vaccination programs in the province, and this also helps in developing plans on how to reduce vaccine hesitancy among parents in Bulacan.