Purpose: This study aims to 1). to analyze the influence of knowledge on Clean and Healthy Living Behavior (PHBS), 2) to analyze the influence of attitudes on Clean and Healthy Living Behavior (PHBS), 3) to analyze the influence of actions on Clean and Healthy Living Behavior (PHBS), 4). to analyze the influence of the availability of facilities and infrastructure on Clean and Healthy Living Behavior (PHBS). 5. To analyze the influence of leadership support on Clean and Healthy Living Behavior (PHBS, 6). To analyze the influence of the Work Environment on Clean and Healthy Living Behavior (PHBS) on Cenderawasih University Education Personnel. Research methodology: The location of the study was at Cenderawasih University, in all Education Personnel in each section at Cenderawasih University totaling 243. The sample in this study used the Lemeshow formula. Stratified random sampling technique of employees totaling 165 employees. Analysis Methodusing Univariate analysis, Bivariate analysis, and Multivariate analysis. Results: The partial research results are: 1). Knowledge has no effect onimplementation of clean and healthy living behavior at Cenderawasih University 2). Attitude influences the implementation of clean and healthy living behavior at Cenderawasih University. 3). Action influences the implementation of clean and healthy living behavior at Cenderawasih University. 4). Facilities and infrastructure influences the implementation of clean and healthy living behavior at Cenderawasih University. 5). Leadership support influences the implementation of clean and healthy living behavior at Cenderawasih University. 6). The work environment does not influence the implementation of clean and healthy living behavior at Cenderawasih University. Conclusions: In general, simultaneously; knowledge, attitudes, actions, infrastructure, leadership support, and work environment influence the implementation of clean and healthy living behavior at Cenderawasih University.